Physics does not permit such ghostly interactions!

"The strong, Cartesian version of free will-the belief that if you were placed in exactly the same circumstances again, including the identical brain state as previously, you could have willed yourself to act otherwise-cannot be reconciled with natural laws. There is no way the conscious mind, the refuge of the soul, could influence the brain without leaving telltale signs. Physics does not permit such ghostly interactions. Anything in the world happens for one or more reasons that are also part of the world; the universe is causally closed."