Saturday, July 14, 2012

Why human body cannot fight HIV infection - The Times of India

Why human body cannot fight HIV infection - The Times of India

The research expanded on an earlier discovery by the Gale lab that HIV directly antagonizes the early innate immune response in infected cells by impairing IRF3 function.

The new studies found that the HIV protein vpu specifically binds to the immune protein IRF3 and targets it for destruction, thereby, preventing IRF3 from functioning to trigger an immune response within the infected cell.

The researchers discovered that the viral protein vpu, which is created by HIV during infection, directly interferes with the immune response protein IRF3 to dampen the ability of the immune system to protect against virus infection.

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